NOTE: This report is compiled on an ongoing basis by MLSsoccer.com editors based on club game notes, news reports, and original reporting. The league does not have an official player availability report.
- OUT: Edwin Mosquera (knee)
- OUT: Jamal Thiaré (shoulder)
Austin FC
- OUT: Julio Cascante (international duty)
- OUT: Dani Pereira (international duty)
- OUT: Junior Urso (lower leg)
- OUT: Chase Gasper (leg)
- OUT: Andrew Gutman (leg)
- OUT: Federico Navarro (leg)
- OUT: Tobias Salquist (leg)
- OUT: Xherdan Shaqiri (international duty)
- OUT: Carlos Terán (leg)
- OUT: Nick Hagglund (leg)
- OUT: Matt Miazga (leg)
- OUT: Malik Pinto (ankle)
Colorado Rapids
- OUT: Moïse Bombito (international duty)
- OUT: Daniel Chacón (knee)
- OUT: Jackson Travis (stress fracture)
- OUT: Evan Bush (arm)
- OUT: Jacen Russell-Rowe (international duty)
FC Dallas
- OUT: Patrickson Delgado (knee)
- OUT: Jesús Ferreira (upper leg)
- OUT: Liam Fraser (upper leg)
- OUT: Geovane Jesus (knee)
- OUT: Paxton Pomykal (knee)
- OUT: Alan Velasco (knee)
D.C. United
- OUT: Conner Antley (knee)
- OUT: Steven Birnbaum (hip)
- OUT: Russell Canouse (not due to injury)
- OUT: Kristian Fletcher (ankle)
- OUT: Jackson Hopkins (back)
- OUT: Garrison Tubbs (head)
Houston Dynamo FC
- OUT: Adalberto Carrasquilla (international duty)
- OUT: Nelson Quinones (knee)
- OUT: Daniel Steres (lower leg)
- OUT: Jefferson Valverde (hip)
- QUESTIONABLE: McKinze Gaines (lower body)
- OUT: Lorenzo Dellavalle (knee)
- OUT: Cristian Olivera (international duty)
- OUT: Gastón Brugman (knee)
- QUESTIONABLE: Jonathan Perez (hamstring)
Inter Miami CF
- OUT: Facundo FarÃas (knee)
- OUT: Nicolás Freire (knee)
- OUT: Lionel Messi (international duty)
- OUT: Luis Suárez (international duty)
Minnesota United FC
- OUT: Hugo Bacharach (knee)
- OUT: Carlos Harvey (international duty)
- OUT: Clint Irwin (leg)
- OUT: Tani Oluwaseyi (international duty)
- OUT: Teemu Pukki (knee)
- OUT: Dayne St. Clair (international duty)
- OUT: Wil Trapp (leg)
- OUT: Mathieu Choinière (international duty)
- OUT: Ariel Lassiter (international duty)
- OUT: Samuel Piette (international duty)
- OUT: Joel Waterman (international duty)
- QUESTIONABLE: Mason Toye (lower body)
Nashville SC
- OUT: Julian Gaines (ankle)
- OUT: Anibal Godoy (lower body)
- OUT: Randall Leal (hip)
- OUT: Lukas MacNaughton (ankle)
- OUT: Jacob Shaffelburg (international duty)
- QUESTIONABLE: Brent Kallman (lower body)
- QUESTIONABLE: Sam Surridge (lower body)
- OUT: Tomas Chancalay (knee)
- OUT: Carles Gil (lower leg)
- OUT: Nacho Gil (knee)
- OUT: Peyton Miller (thigh)
- QUESTIONABLE: Emmanuel Boateng (hamstring)
- QUESTIONABLE: Dylan Borrero (hip)
- QUESTIONABLE: Mark-Anthony Kaye (hip flexor)
- QUESTIONABLE: Tommy McNamara (hamstring)
- QUESTIONABLE: Bobby Wood (calf)
New York City FC
- OUT: Malachi Jones (leg)
New York Red Bulls
- OUT: Carlos Coronel (international duty)
- OUT: Roald Mitchell (knee)
- OUT: Serge Ngoma (knee)
- OUT: Peter Stroud (ankle)
- QUESTIONABLE: Emil Forsberg (foot)
Orlando City SC
- OUT: Mikey Halliday (knee)
- OUT: Mason Stajduhar (leg)
- QUESTIONABLE: David Brekalo (not due to injury)
- QUESTIONABLE: Tahir Reid-Brown (thigh)
Philadelphia Union
- OUT: Alejandro Bedoya (quad)
- OUT: Andre Blake (knee)
- OUT: Isaiah LeFlore (knee)
- OUT: José MartÃnez (international duty)
- OUT: Mikael Uhre (adductor)
- QUESTIONABLE: Markus Anderson (hip)
- QUESTIONABLE: Tai Baribo (back)
Portland Timbers
- OUT: Max Crepeau (international duty)
- OUT: Marvin Loria (lower leg)
- OUT: Eric Miller (leg)
- OUT: Kamal Miller (international duty)
- OUT: Zac McGraw (upper body)
Real Salt Lake
- OUT: Kevin Bonilla (knee)
- OUT: Erik Holt (hamstring)
- OUT: Pablo Ruiz (knee)
- OUT: Marcelo Silva (hamstring)
- OUT: Brayan Vera (not due to injury)
- QUESTIONABLE: Maikel Chang (ankle)
- QUESTIONABLE: Justen Glad (ankle)
- OUT: Daniel (lower body)
- OUT: Carlos Gruezo (international duty)
- OUT: JR Marcinkowski (knee)
- OUT: Jamar Ricketts (lower body)
- OUT: Bruno Wilson (lower body)
- QUESTIONABLE: Carlos Akapo (lower body)
- OUT: Jon Bell (international duty)
- OUT: Braudilio Rodrigues (hamstring)
Sporting Kansas City
- OUT: Felipe Hernández (not due to injury)
- OUT: Logan Ndenbe (knee)
- QUESTIONABLE: Robert Castellanos (ankle)
- QUESTIONABLE: Daniel Salloi (ankle)
- QUESTIONABLE: Remi Walter (knee)
- OUT: Rasmus Alm (knee)
- OUT: Kyle Hiebert (international duty)
- OUT: João Klauss (knee)
- OUT: Joakim Nilsson (hamstring)
- OUT: Tomáš Ostrák (ankle)
- OUT: Célio Pompeu (lower leg)
- OUT: Josh Yaro (head)
Toronto FC
- OUT: Alonso Coello (thigh)
- OUT: Richie Laryea (international duty)
- OUT: Jonathan Osorio (international duty)
- OUT: Brandon Servania (knee)
- OUT: Tyrese Spicer (low back)
Vancouver Whitecaps FC
- OUT: Sam Adekugbe (calf)
- OUT: Ali Ahmed (international duty)
- OUT: Tristan Blackmon (groin)
- OUT: Andrés Cubas (international duty)
- QUESTIONABLE: Damir Kreilach (calf)
